EcoRII endonuclease has two identical DNA-binding sites and cleaves one of two co-ordinated recognition sites in one catalytic event

ABC transporters: one, two or four extracytoplasmic substrate-binding sites?

Two families of ATP-binding cassette (ABC) transporters in which one or two extracytoplasmic substrate-binding domains are fused to either the N- or C-terminus of the translocator protein have been detected. This suggests that two, or even four, substrate-binding sites may function in the ABC transporter complex. This domain organization in ABC transporters, widely represented among microorgani...

One ligand, two regulators and three binding sites: How KDPG controls primary carbon metabolism in Pseudomonas

Effective regulation of primary carbon metabolism is critically important for bacteria to successfully adapt to different environments. We have identified an uncharacterised transcriptional regulator; RccR, that controls this process in response to carbon source availability. Disruption of rccR in the plant-associated microbe Pseudomonas fluorescens inhibits growth in defined media, and comprom...

Gene Sharing Yields an Enzyme with Two Binding Sites in One Subunit

Complexity abounds in the natural world, within us and around us. Consider the human body. We exist thanks to the efforts of an estimated 50 trillion cells—nearly 100 times the number of stars in the Milky Way. Each cell performs a specialized function, conferred by the differential expression of the more than 25,000 protein-encoding genes in the human genome. Proteins are complicated, too; the...

University of Groningen ABC transporters : one , two or four extracytoplasmic substrate - binding sites ?

comparison of the amount of debris extruded apically in two rotary techniques: flexmaster and m2

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